Jović JN. Juvenile myoclonic epilepsy and therapy withdrawal 372 Introduction Juvenile myoclonic epilepsy (JME) is a com- mon idiopathic generalized epilepsy syndrome with the prevalence of 6 to 12% among all patients with epilepsy based on hospital and clinical records

Juvenile myoclonic epilepsy (JME) is a common idiopathic generalized epilepsy syndrome with the prevalence of 6 to 12% among all patients with epilepsy based on hospital and clinical records [1, 2]. As a specific electroclinical syndrome, it is characterized by a genetic predisposition, no evidence of neurological or intellectual deficit and by mandatory or typical myoclonic seizures alone (irregular jerks of the shoulders and arms) or combined with generalized tonic–clonic seizures (GTCS) in 80% or the absence seizures in 15–30%. Bilateral myoclonic seizures and GTCS are provoked by sleep deprivation and predominantly occur after awakening [1, 3, 4]. The seizures may also be precipitated by fatigue, alcohol intake, and stress [4]. Series of myoclonic seizures often precede GTCS